Chelsea Handler's Tour On E! Comes To An End With Final Show

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While Chelsea Handler may not have gotten along with her E! bosses at the end, she still gave them some great programming before she takes her brand to Netflix.

The final edition of "Chelsea Lately" airs tonight and it promises some surprises.

Handler not only broke ground as the first female to achieve long-term success in late night, she also helped launch the careers of a number of comedians who regularly appeared on the show.

Whitney Cummings was among those who got their break from Handler, but the list of comedians who owe the outspoken star is long.

Many of those comedians, as well as a variety of her celebrity friends, will be dropping in on the last show which airs at 11 on E!.

The New York Daily News is reporting that among the guests will be Miley Cyrus who will serenade the departing star with a rendition of Roy Orbison's "It's Over."

Other guests scheduled include former boyfriend 50 Cent, Justin Theroux, Melissa McCarthy, Selena Gomez, Gerard Butler, Minnie Driver, Kristin Chenoweth, Avril Lavigne, James Van Der Beek, Helen Hunt, Johnny Knoxville, Tim Gunn, Vanessa Hudgens, Allison Janney, Kevin Nealon and Marlee Matlin.